Fig. 3: C1QL1 suppresses BrCa cell migration, invasion, EMT and metastasis in vitro and vivo.
From: C1QL1 inhibits breast cancer through the HSP90α/VCP-ERS/UPR axis
a, b MDA-MB-231 and MDA-MB-468 cells stably expressing vector and C1QL1 were subjected to migration assays and Matrigel-coated invasion assays (a) and wound-healing assays (b). c Western blotting analysis of EMT markers in MDA-MB-231 and MDA-MB-468 cells stably expressing vector and C1QL1. d Bioluminescence images and intensity of lung metastasis status of NOD-SCID mice at 16 days after vein injection with vector or C1QL1-transfected MDA-MB-231 cells with luciferase activity. Scale bars, 100 μm. e Kaplan–Meier curves of survival of mice injected with luciferase-labeled MDA-MB-231 cells stably expressing vector and C1QL1.
