Fig. 2 | International Journal of Oral Science

Fig. 2

From: Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways

Fig. 2

S1P agonists attenuate the osteoblastic marker expressions in DPSCs. a The mRNA expression levels of S1PR1–5 in DPSCs were analyzed by qPCR after treatment with osteogenic media for 7 days. b, c The expressions of ALP (b) and COL1A1 (c) in mRNA level were determined by qPCR in DPSCs treated with VPC24191 (10 μmol·L−1) or CYM5520 (10 μmol·L−1) for 7 days; Data are presented as the mean ± SEM. The experiments were at least triplicated. *P < 0.05, ***P < 0.000 5 versus vehicle control. P values were obtained using a Student’s t-test (a–c)

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