Fig. 1
From: High-mobility group box 1 induces endoplasmic reticulum stress and activates hepatic stellate cells
Increased expression of HMGB1 in fibrotic liver. a H&E, Masson’s trichrome staining and Sirius red staining were used to examine the pathological alterations and collagen deposition in TAA-treated rats. b The protein levels of α-SMA, collagen-1 and collagen-3 in fibrotic livers from TAA-treated rats were detected by western blot (n = 2) in each group. c1, c2, c3 The expression of total HMGB1, nuclear HMGB1 and cytoplasmic HMGB1 was measured by western blot (n = 2) in each group. d The expression of HMGB1 in normal and TAA-treated rat sera was detected by ELISA. e The fibrotic liver samples were stained for HMGB1 (green, HMGB1; blue, nuclei). f The normal control (NC) and TAA-treated rats liver tissues were stained for HMGB1 (green, HMGB1; blue, nuclei). **P < 0.01, ***P < 0.0001
