Fig. 2 | Laboratory Investigation

Fig. 2

From: Surfactant dysfunction and alveolar collapse are linked with fibrotic septal wall remodeling in the TGF-β1-induced mouse model of pulmonary fibrosis

Fig. 2

Alveolar microarchitecture on D7. Representative light microscopic images of healthy control (a), Saline D7 (b), and Surf D7 (c). The arrows in b and c point to microatelectases. Microatelectases are absent in a. The following parameters are illustrated: total lung volume (d), total surface area of alveoli per lung (e), total number of open alveoli per lung (f), volume-weighted mean volume of alveoli (g), total volume of septal walls per lung (h), and arithmetic mean thickness of septal walls (i). Data in d to i show individual data and mean of stereological parameters determined at light microscopic level. AdTGF-β1: adenoviral vector-mediated gene transfer of active TGF-β1. Scale bar in a–c: 100 µm

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