Fig. 3 | Laboratory Investigation

Fig. 3

From: Surfactant dysfunction and alveolar collapse are linked with fibrotic septal wall remodeling in the TGF-β1-induced mouse model of pulmonary fibrosis

Fig. 3

Composition of lung parenchyma on D7. Electron microscopic images are presented from healthy control (a), Saline D7 (b), and Surf D7 (c). Stereological data obtained at electron microscopical level are given in d to i and show total volume of collagen fibrils within septal walls (d), total volume of extracellular matrix components other than collagen fibrils within septal walls (e), total volume of interstitial cells within septal walls (f), total volume of alveolar epithelial type 2 cells within septal walls (g), total volume of lamellar bodies per lung (h), and the ratio of the surface area of the apical and baso-lateral membrane of alveolar epithelial type 2 cells (i). Individual data and mean are presented. Scale bar in a–c: 2 µm. Abbreviations: air: distal airspace; col: collagen fibrils; rECM: extracellular matrix other than collagen fibrils; AE2: alveolar epithelial type 2 cell; ery: erythrocyte; cap: capillary lumen; IC: interstitial cells; tm: tubular myelin. AdTGF-β1: adenoviral vector mediated gene transfer of active TGF-β1

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