Fig. 4 | Laboratory Investigation

Fig. 4

From: Surfactant dysfunction and alveolar collapse are linked with fibrotic septal wall remodeling in the TGF-β1-induced mouse model of pulmonary fibrosis

Fig. 4

Alveolar microarchitecture on D14. Representative light microscopic images of healthy control (a), Saline D14 (b), and Surf D14 (c). The arrows in b and c indicate areas of thickened parenchymatous tissue. The following parameters are illustrated: total volume of septal walls per lung (d), arithmetic mean thickness of septal walls (e), total number of open alveoli per lung (f), volume-weighted mean volume of alveoli (g), number-weighted mean volume of alveoli (h), intraindividual SD of the distribution of alveolar sizes (i). In d to i stereological data are presented as individual values and mean. AdTGF-β1: adenoviral vector mediated gene transfer of active TGF-β1. Scale bar in a–c: 200 µm

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