Fig. 8: IL-37b inhibits tumor metastasis in vivo by the degradation of the basement membrane. | Laboratory Investigation

Fig. 8: IL-37b inhibits tumor metastasis in vivo by the degradation of the basement membrane.

From: IL-37bΔ1-45 suppresses the migration and invasion of endometrial cancer cells by targeting the Rac1/NF-κB/MMP2 signal pathway

Fig. 8

A The weight curves of female BALB/c nude mice were shown after intraperitoneal injection with the stably expressed cells (ISK-LV-NC and ISK-LV-IL-37bΔ1-45), and the IL-37bΔ1-45 had no relationship with mice weight (p > 0.05). B The anatomical images of female BALB/c nude mice were represented after intraperitoneal injection with the stably expressed cells (ISK-LV-NC and ISK-LV-IL-37bΔ1-45). C HE staining results confirmed the peritoneal metastatic xenograft model of endometrial cancer had been successfully established (Scale, 100 μm). D IL-37 levels in the LV-IL-37bΔ1-45 group were higher than those in the LV-NC group detected by IHC. E The expression of MMP2 was downregulated in the LV-IL-37bΔ1-45 group compared with the LV-NC group detected by western blot. *p < 0.05; **p < 0.01.

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