Fig. 8: Possible mechanism underlying the AOPPs-induced CYP1A2 and CYP3A4 downregulation. | Laboratory Investigation

Fig. 8: Possible mechanism underlying the AOPPs-induced CYP1A2 and CYP3A4 downregulation.

From: Advanced oxidation protein products downregulate CYP1A2 and CYP3A4 expression and activity via the NF-κB-mediated signaling pathway in vitro and in vivo

Fig. 8

This study demonstrates that AOPPs significantly decrease the CYP1A2 and CYP3A4 expression and activities via direct activation of the NF-κB pathway and induction of nuclear translocation of NF-κB to inhibit the transcription and translation of CYP1A2 and CYP3A4. As inflammatory cytokines, IL-6 and/or TNF-α may mediate this process.

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