Fig. 6: Effects of GAP134 and GAP26 on wound healing in mice. | Laboratory Investigation

Fig. 6: Effects of GAP134 and GAP26 on wound healing in mice.

From: Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway

Fig. 6

a HE staining was performed to evaluate the extent of granulation formation in the NC group, GAP134 group, and GAP26 group on the 7th day after surgery. Scale bar = 250, 75 μm, n = 3. b Western blotting was conducted to detect the expression of Cx43 and pyroptosis-related proteins in different groups at day 7 after surgery. c–e Quantitative analysis of Cx43 and pyroptosis-related proteins expression levels in each group compared with normal group. *P < 0.05, **P < 0.01, #P < 0.05, and ##P < 0.01 vs. NC group, n = 3. f, g ROS levels in different tissues were assayed by using DHE staining. Scale bar = 250, 75 μm. *P < 0.05 and ###P < 0.001 vs. NC group, n = 3.

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