Fig. 6: TINCR inhibited the activation of miR-211-3p-VEGFB-SDF-1α-CXCR4 signalling to suppress TAC-induced cardiac hypertrophy in rats. | Laboratory Investigation

Fig. 6: TINCR inhibited the activation of miR-211-3p-VEGFB-SDF-1α-CXCR4 signalling to suppress TAC-induced cardiac hypertrophy in rats.

From: LncRNA TINCR improves cardiac hypertrophy by regulating the miR-211-3p-VEGFB-SDF-1α-CXCR4 pathway

Fig. 6

A Heart photos and heart weight to tibial length from rats with the indicated treatment. B H&E staining of heart sections and cross-sectional areas of cardiomyocytes. C The relative mRNA expression of VEGFB, SDF-1α, and CXCR4 in cardiac tissues (n = 3). D Western blot analysis of VEGFB, SDF-1α, and CXCR4 in cardiac tissues (n = 3). GAPDH was used as a loading and normalization control. E The relative mRNA expression of ANP and β-MHC in cardiac tissues (n = 3). F Western blot analysis of ANP and β-MHC in cardiac tissues (n = 3). GAPDH was used as a loading and normalization control. G IHC staining of ANP and β-MHC. *P < 0.05, **P < 0.01, and ***P < 0.001.

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