Fig. 8: Mechanism schematic presentation that nesfatin-1 exerts antioxidant, anti-inflammatory, and antiapoptotic effects on acidosis-stimulated chondrocytes via inhibition of ASIC1a expression. | Laboratory Investigation

Fig. 8: Mechanism schematic presentation that nesfatin-1 exerts antioxidant, anti-inflammatory, and antiapoptotic effects on acidosis-stimulated chondrocytes via inhibition of ASIC1a expression.

From: Nesfatin-1 exerts protective effects on acidosis-stimulated chondrocytes and rats with adjuvant-induced arthritis by inhibiting ASIC1a expression

Fig. 8

Nesfatin-1 decreased the phosphorylation of ERK1/2, ubiquitination and degradation of IκBα, and nuclear translocation of NF-κB P65, leading to downregulation of ASIC1a expression. Acid-induced (Ca2+)i elevation was suppressed, andoxidative stress, inflammation, and apoptosis were inhibited.

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