Fig. 3: Histological features of mice with dietary intervention. | Laboratory Investigation

Fig. 3: Histological features of mice with dietary intervention.

From: A diet-induced murine model for non-alcoholic fatty liver disease with obesity and insulin resistance that rapidly develops steatohepatitis and fibrosis

Fig. 3

Representative images of liver sections stained with (A) hematoxylin-eosin (H&E) and (B) Oil Red O at 4 and 12 weeks. Scale bar, 100 μm. C Representative images of macrovescicular steatosis, microvescicular steatosis, hypertrophy and inflammation in liver sections stained with H&E at 12 weeks. Scale bar, 50 μm. D Histological scoring of steatosis and inflammation according to the grading system for rodent NAFLD. Each score was plotted with median (red bar) for 6–8 mice per group. All groups were compared using the Steel-Dwass test. *p < 0.05, **p < 0.01, ***p < 0.001.

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