Fig. 3: Comparing the characteristics between QSC and PSP cellular states. | Leukemia

Fig. 3: Comparing the characteristics between QSC and PSP cellular states.

From: Single-cell analysis reveals the chemotherapy-induced cellular reprogramming and novel therapeutic targets in relapsed/refractory acute myeloid leukemia

Fig. 3

A Heatmap showing the genes expressed in the QSC and PSP cells. Both common and specific genes were shown. B Volcano plot showing the regulons that are specifically activated in the QSCs and PSPs. Regulons highlighted by red are significantly activated in QSCs cells, while regulons highlighted by green are significantly activated in PSPs cells. C Heatmap of metabolic pathways that are specifically activated in QSC-enriched clusters. D The proportion of the QSCs and PSPs in the control group, cytarabine (Ara-C) treated group, and decitabine (DAC) treated group in bulk transcriptomic data (GSE40442) of patient-derived AML samples. Proportions of cellular components are inferred by the deconvolution method CIBERSORTx. Paired Wilcoxon rank-sum test was used to measure the differences between groups. E, F GSEA of the differentially expressed genes between QSCs and PSPs in the gene signatures from diagnostic AML patients with/without CR. Dataset from GSE103424. G, H Kaplan–Meier analysis of OS (G) and relapse (H) of TCGA AML patients. All patients were categorized into two groups based on the median of QSCs percentage. I, J Kaplan–Meier analysis of OS (I) and relapse (J) of TCGA AML patients. All patients were categorized into two groups based on the median of PSPs percentage.

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