Fig. 1: Incidence of severe infections and deaths or a combination of both during induction therapy in the training cohort.

A Frequency of the first severe infection per induction cycle in the overall training cohort and every single trial (HD4, MM5, HD6). The colors indicate the primary infection sites. B Incidence of death per induction cycle in the overall training cohort. The colors indicate the leading causes of death. C Incidence of severe infections and death per induction cycle in the overall training cohort and each single trial (HD4, MM5, and HD6). CNS central nervous system, FUO fever of unknown origin, GI gastrointestinal, GU genitourinary, MM multiple myeloma, TEE thromboembolic event.