Fig. 1: IgG anti-pneumococcal serum antibody concentrations and salivary antibody secretion rates in plasma cell disorder patients and healthy donors.

Data is shown for 12 pneumococcal (Pn) serotypes. Data is presented for all plasma cell disorder (PCD) patients (n = 62) and then subdivided according to disease type/disease activity: MGUS (monoclonal gammopathy of unknown significance), SMM (smouldering multiple myeloma), and MM (multiple myeloma) patients with active disease or in remission. Data is also presented for the HC (healthy control) cohort (n = 40). Data was analysed using the Kruskal-Wallis test and Dunn’s multiple comparisons test. Significant differences between groups are indicated: *p < 0.05, **p < 0.01, ***p < 0.001. **** p < 0.0001. The dotted line on serum panels represents the protective cut-off (0.35 µg/mL). Lines indicate the median, boxes the 25–75th percentile and whiskers the 5-95th percentile.