Fig. 6: Time-dependent assessment of lidocaine by the EMS model. | Microsystems & Nanoengineering

Fig. 6: Time-dependent assessment of lidocaine by the EMS model.

From: Cardiomyocyte electrical-mechanical synchronized model for high-content, dose-quantitative and time-dependent drug assessment

Fig. 6

a Statistical analysis of the time-dependent parameters under lidocaine treatment, including the second amplitude, E4–E6 duration and E3–E4 duration of extracellular potential signals. b Statistical analysis of the time-dependent parameters under lidocaine treatment, including the beating amplitude, M1–M3 duration and M2–M3 duration of mechanical beating signals. c Statistical analysis of the time-dependent parameters under lidocaine treatment, including the E1–M2 duration, E1–M3 duration, E1–M4 duration, E4–M2 duration, E4–M3 duration and E4–M4 duration. d Radar charts of all feature parameters analyzed in a–c after 5, 10 and 15 min of drug treatment. In the radar charts, different concentrations of lidocaine (1.23 μM, 3.7 μM, 11.1 μM, 33.3 μM, 100 μM) displayed specific patterns for a given duration of treatment

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