Table 2 Overview of the electric stimulation paradigm and function

From: Nanomaterial-based microelectrode arrays for in vitro bidirectional brain–computer interfaces: a review

Subject

Sites

Frequency

Amplitude

Duration

Function

Ref.

Cortical culture

2

1/30 Hz

~1/2 Hz

60 ÎĽA

900 s

To study selective adaptation

117

Cortical culture

1, 2

1/50 Hz

0.5–0.7 V

5000 s

To study stimulus-response relations

89

HIP culture

7

1/3 Hz

1 V

450 s

To evoke neuronal activity

80

HIP culture

2

6 Hz

1 V

3600 s

To evoke interval learning

25

HIP slice

1

130 Hz

75% of Maxpp

<15 s

To inhibit low-Mg-induced epilepsy

118

Cortical slice

2

100 Hz

75% of Maxpp

<5 s

To study induced neural enhancement

119

Cortical culture

1

1 Hz

/

20 s

To evoke neuronal activity

120

Cortical culture

1

/

750 mV

/

To study the impact of stimulation temporal distribution

121

HIP culture

8

0.2 Hz

750 mV

300 s

To study the state-dependence of evoked activity

71

HIP culture

1

1 Hz

300 mV

3300 s

To activate learning and memory functions

39

HIP culture

2

/

400–800 mV

1200 s

To study selectivity for the injected information

95

Cortical culture

2

0.2 Hz

12, 24 and 36 µA

>10 h

To study memory trace formation and consolidation

75

SiHa and HeLa culture

1

10 Hz

25 V

/

To enhance transmembrane transport

122

  1. Stimulation duration refers to the total time from the first stimulation to the last stimulation
  2. Maxpp refers to the maximum intensity of postsynaptic potential
  3. HIP refers to hippocampal