Table 2 Overview of the electric stimulation paradigm and function
Subject | Sites | Frequency | Amplitude | Duration | Function | Ref. |
---|---|---|---|---|---|---|
Cortical culture | 2 | 1/30 Hz ~1/2 Hz | 60 μA | 900 s | To study selective adaptation | |
Cortical culture | 1, 2 | 1/50 Hz | 0.5–0.7 V | 5000 s | To study stimulus-response relations | |
HIP culture | 7 | 1/3 Hz | 1 V | 450 s | To evoke neuronal activity | |
HIP culture | 2 | 6 Hz | 1 V | 3600 s | To evoke interval learning | |
HIP slice | 1 | 130 Hz | 75% of Maxpp | <15 s | To inhibit low-Mg-induced epilepsy | |
Cortical slice | 2 | 100 Hz | 75% of Maxpp | <5 s | To study induced neural enhancement | |
Cortical culture | 1 | 1 Hz | / | 20 s | To evoke neuronal activity | |
Cortical culture | 1 | / | 750 mV | / | To study the impact of stimulation temporal distribution | |
HIP culture | 8 | 0.2 Hz | 750 mV | 300 s | To study the state-dependence of evoked activity | |
HIP culture | 1 | 1 Hz | 300 mV | 3300 s | To activate learning and memory functions | |
HIP culture | 2 | / | 400–800 mV | 1200 s | To study selectivity for the injected information | |
Cortical culture | 2 | 0.2 Hz | 12, 24 and 36 µA | >10 h | To study memory trace formation and consolidation | |
SiHa and HeLa culture | 1 | 10 Hz | 25 V | / | To enhance transmembrane transport |