Fig. 1: The expression of NRF2 and its downstream NQO1 and ABCB1 in ESCC tumors. | Modern Pathology

Fig. 1: The expression of NRF2 and its downstream NQO1 and ABCB1 in ESCC tumors.

From: High expression of nuclear NRF2 combined with NFE2L2 alterations predicts poor prognosis in esophageal squamous cell carcinoma patients

Fig. 1

A The distribution of the status of NRF2 expression and NRF2 localization in ESCC patients; (B). IHC staining showed in the tumor with negative expression of NRF2; (C). IHC staining showed in the tumor with positive expression of NRF2 in the cytoplasm; (D), IHC staining showed in the tumor with positive expression of NRF2 in the nucleus; (E), IHC staining showed in the tumor with positive expression of NRF2 in the cytoplasm and nucleus; (F), The difference of NRF2 IHC score among patients with NRF2 positivity; (G), The difference of NQO1 IHC score among patients with NRF2 positivity; (H), The difference of ABCB1 IHC score among patients with NRF2 positivity. *, **, and *** indicates P < 0.05, P < 0.01, and P < 0.001, respectively. NS (not significance) indicates P > 0.05. Each dot in Fig. 1F, 1G, and 1H represents a case with NRF2 positivity.

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