Fig. 1: Schematic representation of the experimental design for Li treatment of hCS. | Molecular Psychiatry

Fig. 1: Schematic representation of the experimental design for Li treatment of hCS.

From: Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids

Fig. 1

Fibroblasts isolated from 10 controls (CTRL) and 11 bipolar disorder (BD) patients, including 5 lithium non-treated (Li-N) and 6 Li-responders (Li-R), were reprogrammed to induced pluripotent stem cells (iPSCs) and differentiated to cortical spheroids (hCS). All 21 hCS lines were treated with 1 mM lithium (Li) and water as vehicle control. Medium-to-long-term effects of drug exposure (1 month) were assessed through transcriptional profiling and functional analyses in 180-day-old hCS.

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