Fig. 5: Li-associated DEGs and GO enrichment analysis of hCS stratified by diagnostic and response status. | Molecular Psychiatry

Fig. 5: Li-associated DEGs and GO enrichment analysis of hCS stratified by diagnostic and response status.

From: Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids

Fig. 5

a Volcano plot of all DEGs identified for the untreated (Li-) BD vs. CTRL hCS. b Volcano plot of all DEGs identified for the treated (Li+) vs. untreated (Li−) hCS, independent of diagnosis. c Gene ontology (GO) pathway analysis (biological processes) of the 132 Li-associated DEGs identified in all samples independent of diagnosis. d, e Volcano plots of all Li-associated DEGs identified in CTRL and BD hCS, respectively. f GO pathway analysis of the Li-associated DEGs (74) that were unique to CTRL hCS (gray) and DEGs (8) that were unique to BD hCS (blue). g, h Volcano plots of all Li-associated DEGs in Li-N and Li-R hCS, respectively. i GO pathway analysis of the Li-associated DEGs [29] that were unique to Li-N hCS (dark blue) and DEGs [5] that were unique to Li-R hCS (light blue). CTRL (N = 10), Li-N (N = 5), Li-R (N = 6).

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