Fig. 5: Cognitive impairment in Satb2 conditional KO.
From: CDKL5 sculpts functional callosal connectivity to promote cognitive flexibility
a Latency to platform during the 5 trials in learning phase in control and cKO mice (two-way Anova, interaction trial x genotype, p = 0.1865, Sidak’s multiple comparison: trial 1: p = 0.4394, Trial 2: p = 0.0334*, Trial 3, p = 0.9998, Trial 4: p = 0.0143*, Trial 5:0.1991). b Memory was then tested the following day (two-way Anova, Sidak’s multiple comparison within genotypes between expected vs. opposite quadrant, Ctrl: p < 0.0001, cKO: p = 0.0024). c Latency to platform when it has moved to a new ___location (two-way Anova, interaction genotype × trial, p = 0.6529, Sidak’s multiple comparison, Trial 1: p = 0.5732, Trial 2, p = 0.8332, Trial 3: 0.4021). Ctrl: n = 15 mice, cKO: n = 14 mice. d Four-choice foraging task paradigm. e (Left) Number of trials needed to reach criterion during the discrimination task (Ctrl: 11.50 ± 1.06, n = 12mice; cKO: 18.55±3.26, n = 11mice, Mann-Whitney test p = 0.065). (Right) Total number of errors during the discrimination task (Ctrl: 2.33 ± 0.60, cKO: 6.91 ± 2.21; Mann-Whitney test p = 0.0439*). f (Left) Number of trials to reach criterion during the reversal phase (Ctrl: 16.42 ± 1.549; cKO: 20.09±1.979, Mann-Whitney test p = 0.1132). (Right) Total number of errors during the reversal task (Ctrl: 6.250 ± 0.962, cKO: 10.82 ± 1.742, unpaired t-test p = 0.0287). g (Left) Number of trials to reach criterion in the spatial shift (Ctrl: 18.67 ± 2.647; cKO: 20.45 ± 1.826, Mann-Whitney test p = 0.3693). (Right) Total number of errors during the task (Ctrl: 6.333 ± 1.345, cKO: 8.00 ± 0.9439, Mann-Whitney test p = 0.1926). Mean ± SEM.
