Fig. 4: Group differences in functional connectivity measured by generalized psychophysiological interaction (gPPI) contrasting aversive versus neutral anticipation in the AV task (AV_aver>AV_neu). | Molecular Psychiatry

Fig. 4: Group differences in functional connectivity measured by generalized psychophysiological interaction (gPPI) contrasting aversive versus neutral anticipation in the AV task (AV_aver>AV_neu).

From: Mechanisms underlying capsulotomy for refractory obsessive-compulsive disorder: neural correlates of negative affect processing overlap with deep brain stimulation targets

Fig. 4

A Sagittal slice showing disease and treatment effects on the functional coupling of right NAc (seed) —rACC / vmPFC. Red-outlined squares on the left indicated significance at pvoxel < 0.001, pcluster < 0.05 FDR correction. B Mean right NAc – rACC / vmPFC connectivity (gPPI estimate) extracted from regional cluster of significance (pvoxel < 0.005, pcluster < 0.05 FDR correction) revealed significantly decreased functional connectivity in patients after capsulotomy compared to OCD controls contrasting aversive versus neutral anticipation (AV_aver>AV_neu). CAP obsessive-compulsive disorder (OCD) capsulotomy patients, HC healthy controls, OCDc OCD controls, AV aversive avoidance task, EV aversive extinction task, NAc nucleus accumbens, rACC rostral anterior cingulate cortex, vmPFC ventromedial prefrontal cortex. **p < 0.01, ***p < 0.001.

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