Table 1 Genomic loci associated with BAG.

From: Genetic architecture of brain age and its causal relations with brain and mental disorders

Locus

Lead SNP

POS

Gene

A1

A2

Beta

I2

P

Chr3:183892867-183975709

rs73185796

183975709

CAMK2N2/ECE2

T

G

āˆ’0.29

0.0

2.53 Ɨ 10āˆ’8

Chr4:38591172-38779512

rs13132853

38680015

KLF3

G

A

0.23

0.0

2.34 Ɨ 10āˆ’18

Chr5:78388694-78451813

rs79107704

78388694

BHMT2

A

G

0.63

0.0

1.65 Ɨ 10āˆ’8

Chr6:45407654-45511945

rs2790102

45432214

RUNX2

A

G

āˆ’0.15

0.0

8.92 Ɨ 10āˆ’9

Chr8:124661974-124682971

rs7461069

124669029

KLHL38

A

G

āˆ’0.17

0.0

1.57 Ɨ 10āˆ’8

Chr10:134544247-134597265

rs4880424

134584577

INPP5A

T

C

0.16

64.95

3.69 Ɨ 10āˆ’8

Chr14: 88391116-88556525

rs17203398

88449847

GALC

C

G

āˆ’0.16

40.97

1.42 Ɨ 10āˆ’10

Chr17: 43101281-44863413

rs2106786

43919096

MAPT

G

A

0.29

0.0

1.87 Ɨ 10āˆ’23

  1. Eight independent genomic loci significantly associated with brain age gap (BAG). Lead SNP rs-number, genomic position (in hg19 coordinates), effective allele (A1), the other allele (A2), effect size (Beta), meta-analysis heterogeneity (I2), association strength (P value, P).
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