Fig. 1: KO mice lacking astrocytic factor CRTC3 show lower social dominance. | Molecular Psychiatry

Fig. 1: KO mice lacking astrocytic factor CRTC3 show lower social dominance.

From: Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse

Fig. 1

a Tube dominance test. b Number of winning points with WT and CRTC3 KO. WT (n = 33), KO (n = 20). c, d The number and mean duration of pushes initiated (c) and push-backs (d), WT (n = 67), KO (n = 67). Percentage of time that mice resisted while being pushed (e) or retreated while being pushed (f), WT (n = 31), KO (n = 58). g Time spent in the warm spot (left) and the rank (right) obtained in the warm spot test, WT (n = 64), KO (n = 36). h The percentage of wins in the tube dominance test in familiar groups (left) WT (n = 51), KO (n = 28) and in unfamiliar groups (right) WT (n = 12), KO (n = 11). i Winning points in the tube dominance test by WT and CRTC3 KO mice of equal weight, WT (n = 17), KO (n = 17). j The resting-state functional connectivity matrices of social dominance-related brain ROIs from WT (left) and CRTC3 KO (middle) mice are represented. The mean difference map is represented (right). k Compared with WT, CRTC3 KO mice show significantly decreased mean z-CorrCoef across all focused matrices between the ROI groups of the prefrontal cortex (PFC) and posterior parietal cortex (PTLp). L: left and, R: right hemispheres. WT (n = 19), KO (n = 19), Mann-Whitney test, Chi-square, Unpaired t-test. **p < 0.01, ***p < 0.0001. Error bars, SEM.

Back to article page