Fig. 3: Regional plot for EWAS results in participants who never smoked cigarettes (a) and GWAS results (b) for lifetime cannabis use around the genes APOBR/CLN3.
The x-axis shows the genomic position in base pair (bp) in hg19, while the y-axis shows the significance of associations (−log10 p-values). a Each dot is a CpG probe, and the red dotted line indicates the epigenome-wide significance at FDR < 0.05. b Each dot is a SNP site, and the colors show different levels of LD in \({r}^{2}\). The box in the bottom includes the genes within the genomic region, and genes underlined in yellow were significant in the gene-based test while those underlined in green were identified in the S-PrediXcan analysis [45].
