Fig. 2: Altered lipid profile in ABCA7−/− iPSC-derived cortical organoids.
From: ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism
Lipidomics was performed in the cortical organoids derived from isogenic control and ABCA7−/− iPSCs (#1). Three iPSC organoids cultured in an identical dish were lysed together and analyzed as one sample (n =  6 technical replicates/line). All lipid concentrations were normalized to total protein levels. A Major lipid species with significant differences are shown. Data represent mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001 by two-tailed student’s t-test. B Heat map of lipid subspecies altered by ABCA7 deficit is shown. C The correlation between lipid module eigengenes and ABCA7 deficit is shown. D The black, yellow, and blue modules showed a correlation with p < 0.05. The FDR of the top 5 hub lipids was visualized.
