Fig. 2: Structural Equation Models. | Molecular Psychiatry

Fig. 2: Structural Equation Models.

From: Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study

Fig. 2

Child conduct problems (CPC) are modelled as a latent factor, indicated by eight ordinal items of the conduct disorder subscale of the RS-DBD. The model is initially analysed separately for the 13 different polygenic scores (e.g., PGS for ADHD, PGS for depression). Genetic transmission effects (orange paths), e.g., for the mothers, are estimated as the pathway PGSM → PGSC → PC which effectively is ~0.5 × βC and can be considered as a mediation or indirect effect of parental polygenic scores on child outcomes via the respective child polygenic score. Associations between child and parental polygenic scores vary around the expected value of 0.5, and estimated values are used in the calculation of genetic transmission effects (see Supplementary Table S9). The models allow the maternal and paternal polygenic scores to covary.

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