Fig. 3: Comparison of the activities of aripiprazole and cariprazine with 5-HT in the agonist mode. | Molecular Psychiatry

Fig. 3: Comparison of the activities of aripiprazole and cariprazine with 5-HT in the agonist mode.

From: Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor

Fig. 3

Graphs comparing the maximal response of aripiprazole and cariprazine with that of 5-HT at Gαq (a), Gα11 (b), Gα14 (c) and Gα15 (d) (mean ± SEM; n = 3; one-way ANOVA followed by Dunnett’s post hoc test). **p = 0.0046 for aripiprazole and **p = 0.0047 for cariprazine in a, **p = 0.0023 in b, *p = 0.0169, and ***p = 0.0007 for c and ****p < 0.0001 for d, compared to the maximal response by 5-HT at the respective pathways.

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