Fig. 5: GWAS results for break point achieved during the progressive ratio test. | Molecular Psychiatry

Fig. 5: GWAS results for break point achieved during the progressive ratio test.

From: Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats

Fig. 5

a Regional association plot for chromosome 19, with the top SNP in purple and the color of other significant SNPs referring to level of linkage disequilibrium with the top SNPs. The ___location of the top SNP is indicated on the plot. Known genes of SNPs are indicated below the plots. b Effect plots showing break point achieved during the progressive ratio test (left: normalized data, right: raw data) for OUD vulnerable (pink) and intermediate/resilient (yellow) rats in relation to the top SNP allelic variant. Half a violin plot is shown for each OUD phenotype, with the solid line indicating the median value of the data set, whereas the dashed lines represent the upper and lower interquartile range. c OUD phenotypic cluster composition for both peak SNP allelic variants. Cluster composition between variants differed (x2(1, 864) = 18.91, p < 0.0001), with the minor allele heavily biased toward an OUD vulnerable phenotype. Significance threshold: red line, p < 0.10; blue line, p < 0.05. (n = 864; Vulnerable (pink), n = 345; Intermediate/resilient (yellow), n = 519).

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