Fig. 8 | Mucosal Immunology

Fig. 8

From: Small heat shock protein CRYAB inhibits intestinal mucosal inflammatory responses and protects barrier integrity through suppressing IKKβ activity

Fig. 8

TAT-CRYAB administration ameliorates DSS-induced intestinal damages. Water + PBS group: three mice; water + TAT-CRYAB group: three mice; DSS + PBS group: four mice; DSS + TAT-CRYAB group: four mice. a Epithelial permeability was measured on day 7 post-DSS treatment by oral administration of FITC-dextran. ***p < 0.001. b Representative images of Alcian blue/periodic acid-Schiff staining of colon tissues from mice of different groups (magnification: ×200, upper panels; ×400, lower panels). c Representative immunofluorescence images for ZO-1 in colonic tissues from different groups of mice (magnification: ×400). d E-cadherin expression in colonic tissues from different groups was examined by immunoblotting; *p < 0.05. e Representative immunofluorescence images for E-cadherin, CK20, and MUC2 in colonic tissues from different groups of mice (magnification: ×400). All data are shown from three independent experiments

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