Fig. 2: HFD-induced obese mice exhibit delayed C. difficile clearance. | Mucosal Immunology

Fig. 2: HFD-induced obese mice exhibit delayed C. difficile clearance.

From: Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice

Fig. 2

Proportion of mice with detectable C. difficile on days 3 and 10 of CDI; Fraction on top of each bar indicates the # of mice with detectable C. difficile over total # of mice challenged with C. difficile (a). C. difficile spores, vegetative bacteria (b) and toxin A and B levels (c) in cecal contents of RD-fed and HFD-fed mice. b, c Samples with detectable C. difficile on day 3 and day 10 after infection were used. Data are means ± SEM. n = 10–18 for a–b; n = 7–9 for c; pooled from 2 to 3 experiments. *p < 0.05, n.s. non-significant; two-tailed Student’s t-test.

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