Fig. 4: Restoration of gut microbiota and restitution of microbial enzymes is delayed in obese mice. | Mucosal Immunology

Fig. 4: Restoration of gut microbiota and restitution of microbial enzymes is delayed in obese mice.

From: Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice

Fig. 4

Shrinkage linear discriminant analysis of species that significantly affect the microbial community on day 10 of CDI (Cut off p value set at 0.025 and effect size at 0.3) (a). Abundance of Lachnospiraceae (b) and Clostridiaceae (c) in cecal contents. Graphic representation of influence of microbial recolonization on BA metabolism (d). Number of reads of bile salt hydrolase (e) and Bile acid 7-α dehydroxylase (f) genes in cecal contents. Data are means ± SEM. n = 2–5. *p < 0.05; **p < 0.01; ***p < 0.001, n.s. non-significant; two-tailed Student’s t-test.

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