Fig. 5: CDI alters BA homeostasis in HFD-fed mice. | Mucosal Immunology

Fig. 5: CDI alters BA homeostasis in HFD-fed mice.

From: Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice

Fig. 5

Relative amounts of BA metabolites in cecal contents of RD-fed and HFD-fed mice are displayed as a heat map. Each sub-column represent BA profile of individual mice (a). Concentration of primary BAs (b) and secondary BAs (c). Ratio of BAs that are C. difficile spore germinants (TCA and CA) to those that are germination inhibitors (CDCA, UDCA, αMCA, βMCA, ωMCA, HDCA, LCA and DCA) (d) concentration of BAs that inhibit C. difficile growth (CDCA, UDCA, ωMCA, HDCA, LCA, and DCA) (e) in cecal contents. Data are means ± SEM. n = 4–5. *p < 0.05; **p < 0.01, ***p < 0.001, n.s. non-significant; two-tailed Student’s t-test.

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