Fig. 6: CDI alters concentration of cecal FXR ligands in HFD-fed mice and increases primary BA synthesis. | Mucosal Immunology

Fig. 6: CDI alters concentration of cecal FXR ligands in HFD-fed mice and increases primary BA synthesis.

From: Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice

Fig. 6

Pearson correlation of serum C4 and conjugated primary bile acids in cecal contents (a). Serum C4 levels in RD-fed and HFD-fed mice (b). Schematic representation of hepatic BA synthesis feedback regulation by FXR signaling. BAs that are FXR agonists trigger the transcription and release of fibroblast growth factors (FGFs) 15/19 that inhibit Cyp7A1, the rate-limiting enzyme in hepatic BA synthesis (c). Concentration of CDCA, CA, DCA, and LCA in cecal contents (d). Percentage of BAs that are FXR agonists (e), antagonists (f) and ratio of FXR agonists to antagonist (g) in cecal contents. Data are means ± SEM. n = 28 for a; n = 4–5 per group for b, d–g. *p < 0.05, **p < 0.01, ***p < 0.001, n.s. non-significant; two-tailed Student’s t-test.

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