Fig. 2: Nodal centrality differences between bipolar and healthy subjects across time points.

The nodes were mapped onto the cortical surfaces by using the BrainNet Viewer package (http://www.nitrc.org/projects/bnv). The nodal centrality differences between bipolar and healthy subjects at baseline did not survive application of an FDR threshold of q = 0.05, so the nodal results are presented with nominal significance thresholds for heuristic purposes. IFGtriang Inferior frontal gyrus, triangular part, ORBinf Inferior frontal gyrus, orbital part, ORBsupmed Superior frontal gyrus, medial orbital, ACG Anterior cingulate and paracingulate gyri, DCG Median cingulate and paracingulate gyri, PCG Posterior cingulate gyrus, PHG Parahippocampal gyrus, PoCG Postcentral gyrus, SPG Superior parietal gyrus, CAU Caudate, TPOmid Temporal pole: middle temporal gyrus, PUT Putaman, MTG Middle temporal gyrus, AMYG Amygdala. R = right hemisphere; L = left hemisphere.