Fig. 3: Change in regional network measures over the course of treatment and correlation to YMRS change in individuals with bipolar disorder. | Neuropsychopharmacology

Fig. 3: Change in regional network measures over the course of treatment and correlation to YMRS change in individuals with bipolar disorder.

From: Changes in the structural brain connectome over the course of a nonrandomized clinical trial for acute mania

Fig. 3

A Nodal efficiency of left anterior cingulate showed significant group-by-time interaction effects (F = 3.36, p = 0.03). B Nodal efficiency of left posterior cingulate gyrus showed significant group-by-time interaction effects (F = 4.12, p = 0.02). C Changes in nodal efficiency of left anterior cingulate significantly correlated with changes in YMRS score (r = 0.35, p < 0.001). D Changes in nodal efficiency of left posterior cingulate significantly correlated with changes in YMRS score (r = −0.22, p = 0.02). ACG Anterior cingulate and paracingulate gyri, HC Healthy individuals, L Left, P Patients with bipolar disorder, PCG Posterior cingulate gyrus, WK Week, YMRS Young Mania Rating Scale.

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