Fig. 2: 5-HT1A autoreceptor knockdown rescues ELA effects on behavioral and endocrine response to adult stress in females. | Neuropsychopharmacology

Fig. 2: 5-HT1A autoreceptor knockdown rescues ELA effects on behavioral and endocrine response to adult stress in females.

From: Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors

Fig. 2

a Experimental timeline of ELA (P3-10), acute swim stress exposure, and blood collection in adolescence (P35). b, c No difference in immobility time between adolescent WT and 5HT1A K.D. control vs. ELA-exposed females. d 5HT1A K.D. reduces CORT levels compared to WT mice in adolescent females regardless of rearing condition. e, f 5HT1A K.D. decreases immobility time in adolescent males. g ELA or 5HT1A K.D. does not affect baseline or post-FST CORT responses in adolescent males. h Experimental timeline of ELA (P3-10), acute swim stress exposure, and blood collection in adulthood (P56). i, j ELA increases immobility in the FST in adult females compared to standard-reared control females. 5HT1A K.D. reduces immobility in ELA-exposed females. k In WT females, ELA increases post-FST CORT responses compared to controls. No effect of ELA on CORT is observed in 5-HT1A K.D. females. l, m No difference in immobility between adult WT and 5HT1A K.D. control vs. ELA-exposed males. n Neither ELA nor 5-HT1A K.D. affect baseline or post-FST CORT responses in adult males. FST – Forced Swim Test. Mean ± SEM; *P < 0.05, **P < 0.01.

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