Fig. 4: 5-HT1A autoreceptor knockdown rescues ELA effects on adult hippocampal neurogenesis in the female vDG. | Neuropsychopharmacology

Fig. 4: 5-HT1A autoreceptor knockdown rescues ELA effects on adult hippocampal neurogenesis in the female vDG.

From: Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors

Fig. 4

a Experimental timeline. b Representative images of DCX+ cells in the female vDG at P56. c In adolescence (P35), ELA or 5HT1A K.D. did not affect the number of DCX+ cells in the vDG of females, or d males. e In adulthood (P56), ELA decreased the number of DCX+ cells in the vDG of WT females compared to controls. This ELA effect was rescued in females with 5HT1A K.D. f ELA or 5HT1A K.D. did not affect the number of DCX+ cells in the vDG of adult males. DCX – Doublecortin. Mean ± SEM; *P < 0.05; **P < 0.01.

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