Fig. 8 | Oncogene

Fig. 8

From: EGF-induced nuclear localization of SHCBP1 activates β-catenin signaling and promotes cancer progression

Fig. 8

SHCBP1 expression is associated with β-catenin signaling activity and CSCs properties in NSCLC. a WB analyses exhibit the nuclear SHCBP1 protein levels in eight NSCLC tumor specimens (T) and their paired adjacent non-cancerous lung tissue (N). b Kaplan–Meier analysis of overall survival of 207 NSCLC patients which were grouped according to nuclear SHCBP1 expression assessed by immunohistochemistry analysis. c IHC was carried out in paraffin-embedded sections derived from 50 NSCLC patients. Correlations between nuclear SHCBP1 and Axin2, CCDN1 and survivin were analyzed by chi-squared test. d GSEA analysis to determine the correlation between SHCBP1 expression and β-catenin signaling activation. e GSEA analysis in TCGA NSCLC patients. Correlation between SHCBP1 and stemness-associated signature was identified and listed

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