Fig. 2

CBAP downregulation prolongs the survival of leukemic mice. a Tracking of leukemia outgrowth by bioluminescence imaging in NSG mice transplanted with sh-Ctrl- or sh-CBAP-expressing Jurkat cells (n = 2 per group). + represents mouse death. b–d Kaplan–Meier plots showing the mortality of NSG mice transplanted with various Jurkat clones (b, c) or CCRF-CEM clones (d) as indicated. Animal numbers in (b): for sh-Ctrl, n = 12, for sh-CBAP(no.1), n = 12, sh-CBAP(no.2), n = 5; in (c): cr-Ctrl, n = 15, CBAP-KO, n = 15, CG5, n = 15; in d: for sh-Ctrl, n = 10, sh-CBAP, n = 10. The survival results in b–d were compiled from experiments performed with aforementioned lines (see also results in Supplementary Fig. S3 for individual clones). The statistical significance of differences in the survival curves between groups was evaluated using the log-rank test