Fig. 5

Reduction of Dll1 in mouse luminal tumors leads to decreased proliferation and angiogenesis. a, b Representative IHC images show reduced proliferation (Ki67⁺ cells) (a) and CD31⁺ blood vessels (b) in WTB Dll1-KD (KD2 and KD4) primary tumors compared to control. c Representative IF images show reduced CD34⁺ blood vessels in WTB Dll1-KDs (KD2 and KD4) primary tumors compared to control. Quantification is shown in the right of each set of images. a−c Mann−Whitney U test to compute p values. Scale bars, 40 µm (a−c). Data are presented as the mean ± SEM. **p < 0.01 and ***p < 0.001. IHC images were quantified from ten random fields and three different samples per group were used. FOV field of view