Fig. 7
Downregulation of miR-10b and miR-222 inhibited tumor growth in vivo. a Representative luminescence imaging for As-miR-10b/222 transfected LN229-luc tumors versus scramble-treated controls (images were taken in the third week after treatment). b PTEN and p53 expression after transfecting in tumor sections following IHC analysis (*the bars represent 100 μm). c Schematic representation of the pattern for miR-10b and miR-222 participated in tumorigenicity of GBM. Model summarizes the contribution of miR-10b and miR-222 to target PTEN and BIM to suppress p53 pathway. PUMA, p21 and p27 were also involved in the regulation of tumor by miR-10b/222. MiR-10b target gene was shown in yellow. MiR-222 target genes were shown in green. Co-target genes by miR-10b and miR-222 were shown in red
