Fig. 3
From: ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942
ABC-transporter mediated efflux is altered in ICEC0942-resistant cells. MCF7 and MCF7-942R were incubated with EFFLUXX-ID dye (a), and MCF7 and MCF7-THZ1R with Hoechst 33342 (c), and the accumulation of intracellular fluorescence was measured by flow cytometry every 5 min for 30 min (error bars = SEM, n = 3). The mean fluorescence intensity at time 0 and 30 min is shown for MCF7 vs. MCF7-942R (b) and MCF7 vs. MCF7-THZ1R (d) (error bars = SEM, n = 3). Asterisks represent statistically significant differences (unpaired t-test, *P < 0.05, ****P < 0.0001)
