Fig. 8: STAP-1 is a possible therapeutic target in CML.
From: Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML
a Lin− CD34+ BM cells were collected from newly diagnosed chronic CML patients (n = 6), and cultured in triplicates in liquid medium with or without 1 μM imatinib for 24 h. Total RNA samples isolated from these cells were quantified by real-time RT-PCR (n = 6 per group). Results are normalized to the untreated cells. Data are shown as mean ± SD. NS not significant. b Model for the role of STAP-1 in CML LSCs. STAP-1 binds to BCR-ABL and STAT5. STAP-1 positively regulates STAT5 phosphorylation status followed by change in cellular apoptosis and drug sensitivity in CML.
