Fig. 7: Model of PRMT1-mediated NONO arginine methylation in CRC progression.
From: PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer
In CRC cells, PRMT1-mediated methylation of NONO at R251 promotes tumor cell proliferation and metastasis. Malignant progression induced by NONO arginine methylation may be abrogated by treatment with small-molecule inhibitors of PRMT1 (AMI-1, MS023, and C7280948).
