Fig. 2: Comparative analysis of tissue-derived mutations and their representation in LB samples.

Patients were categorized into two sub-groups referring to A high-input and B low-input cfDNA samples used for NGS analysis (≥30 and <30 ng, respectively). ‡Multiple mutations were detected in the same gene. FIC density gradient centrifugation-enriched CTCs, LB liquid biopsy, LR local recurrence, NGS next-generation sequencing, ROS RosetteSep™-enriched CTCs, tDNA tumor-derived DNA.