Fig. 8: High-POU2F1 and ALDOA expression is associated with the worst prognosis of colon cancer patients. | Oncogene

Fig. 8: High-POU2F1 and ALDOA expression is associated with the worst prognosis of colon cancer patients.

From: The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity

Fig. 8

Based on the levels of POU2F1 and ALDOA expression by IHC, 184 Colon cancer patients were stratified into the POU2F1high/ALDOAhigh (n = 118), POU2F1high/ALDOAlow (n = 8), POU2F1low/ALDOAhigh (n = 6), and POU2F1low/ALDOAlow (n = 52). A, B Their OS and PFS were analyzed. Data are survival curves of each group of patients. C A schematic diagram illustrates the mechanisms by which the POU2F1-ALDOA axis regulates the malignancy and oxliplatin resistance of colon cancer. POU2F1 enhances the glycolytic flux and PPP flux by up-regulating the ALDOA expression through directly binding to its promoter region. As a result, the enhanced glycolysis enhances the production of lactate, which can promote the proliferation and induce the oxliplatin resistance in colon cancer. Meanwhile, POU2F1 enhances the PPP activity to increase the production of NADPH, which can reduce the intracellular ROS levels and cancer cell apoptosis. The enhanced PPP activity also increases the production of R-5-P to enhance DNA synthesis, ultimately contributing to the proliferation and oxliplatin resistance in colon cancer.

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