Fig. 4: LZTFL1 induces cell cycle arrest at G1/S transition. | Oncogene

Fig. 4: LZTFL1 induces cell cycle arrest at G1/S transition.

From: LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway

Fig. 4

a GO terms of differentially expressed genes (DEGs) between lower and upper quartile expression of LZTFL1 in TCGA-ccRCC cohort. Count indicates the number of DEGs enriched in the pathway. GeneRatio indicates the ratio of enriched DEGs to background genes. b Flow cytometry cell cycle analysis of ACHN and A498 cells stably overexpressing LZTFL1 and knockdown, respectively, and their respective control cells (left panels). Percentages (%) of cell populations at different cell cycle phases (right panels). mean ± SD of three independent experiments, *, P < 0.05, **, P < 0.01, unpaired student t test. c Representative immunofluorescent staining of Edu (red) and DAPI (blue) of cells indicated (left panel) and % of Edu-positive cells (right panel). Mean ± SD of three independent experiments, ***, P < 0.001, ****, P < 0.0001, unpaired student t test. scale bar is 60 μm.

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