Fig. 7: LZFL1 inhibits ccRCC growth in patient-derived xenograft (PDX) model. | Oncogene

Fig. 7: LZFL1 inhibits ccRCC growth in patient-derived xenograft (PDX) model.

From: LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway

Fig. 7

a Tumor micrograph (left panel) and weight (right panel) at time of sacrifice from PDXs treated with lentiviruses expressing control vector (NC) or LZTFL1. Mean ± SD, *, P < 0.05, unpaired t-test. b Tumor volume during treatment. Mean ± SEM, *, P < 0.05, two-way ANOVA. c H&E and IHC staining of PDX tumors, scale bar is 100 μm. d Schematic diagram of the role of LZTFL1 in ccRCC. LZTFL1 binds to ZNRF1 and AKT, promotes AKT degradation through the UPP pathway, leading to cell cycle arrest and inhibition of ccRCC growth.

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