Fig. 2: Silencing YTHDF2 inhibits MM cell proliferation, and causes G1/S phase cell cycle arrest. | Oncogene

Fig. 2: Silencing YTHDF2 inhibits MM cell proliferation, and causes G1/S phase cell cycle arrest.

From: N6-methyladenosine reader YTHDF2 promotes multiple myeloma cell proliferation through EGR1/p21cip1/waf1/CDK2-Cyclin E1 axis-mediated cell cycle transition

Fig. 2

A, B Validation of YTHDF2 knockdown at both mRNA and protein levels in RPMI-8226 and NCI-H929 MM cell lines. C, D Cell viability was detected by CCK8 assays in RPMI-8226 and NCI-H929 cells transfected with siNC and siYTHDF2. E, F Cell proliferation was measured by EdU assay in RPMI-8226 and NCI-H929 cells transfected with siRNAs. G, H Cell cycle was detected by PI-staining in RPMI-8226 and NCI-H929 cells transfected with siNC and siYTHDF2. Data are mean ± SD values. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, n.s. not significant.

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